Vacuolar proteases livening up programmed cell death

Research output: Contribution to journalShort surveypeer-review

45 Scopus citations


The molecular identity of the key executioners involved in controlling plant programmed cell death (PCD) has been elusive. In a recent paper published in Science, Hatsugai and coworkers reported that a well-characterized protease called VPE from the plant cell vacuole can cleave caspase-specific substrates and is required for cell death activation by tobacco mosaic virus. This work provides clear evidence for the importance of the vacuole in plant PCD and a novel regulatory function for this organelle as well as for VPE proteases.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalTrends in Cell Biology
Issue number3
StatePublished - Mar 2005

All Science Journal Classification (ASJC) codes

  • Cell Biology


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