Vacuum-assisted closure instill as a method of sterilizing massive venous stasis wounds prior to split thickness skin graft placement

Wissam Raad, John C. Lantis, Leslie Tyrie, Cynthia Gendics, George Todd

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Patients with massive venous stasis ulcers that have very high bacterial burdens represent some of the most difficult wounds to manage. The vacuum-assisted closure (VAC) device is known to optimise wound bed preparation; however, these patients have too high a bacterial burden for simple VAC application to facilitate this function. We present the application of the VAC with instillation of dilute Dakins solution as a way of bacterial eradication in these patients. Five patients with venous stasis ulcers greater than 200 cm2 that were colonised with greater than 105 bacteria were treated with the VAC instill for 10 days with 12·5% Dakins solution, instilled for 10 minutes every hour. Two patients had multi-drug-resistant pseudomonas, three with MRSA. All the five had negative quantitative cultures, prior to split thickness skin graft with 100% take and complete healing at 1 year. Adequate delivery of bactericidal agents to the infected tissue can be very difficult, especially while promoting tissue growth. By providing a single delivery system for a bactericidal agent for a short period of time followed by a growth stimulating therapy, the VAC instill provides a unique combination that appears to maximise wound bed preparation.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalInternational Wound Journal
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2010

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Keywords

  • Negative pressure wound therapy
  • Split thickness skin graft
  • Wound sterilisation

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