Abstract
The effects of vagal denervation (VD) were examined on responses of Na+ and water excretion to acute volume expansion (18 ml/kg of 6% dextran in saline) in six conscious rhesus monkeys with chronic sinoaortic denervation (SAD). After SAD, volume expansion increased mean arterial pressure (from 95 ± 6.6 to 119 ± 7.5 mmHg), right atrial pressure (from 1.3 ± 0.7 to 5.9 ± 1.8 mmHg), urine flow (from 0.08 ± 0.01 to 0.68 ± 0.20 ml/min), and Na+ excretion (from 1.30 ± 0.45 to 29.51 ± 10.40 μeq/min). After VD, volume expansion increased mean arterial and right atrial pressures similarly, but induced significantly lower (P<0.05) increases in urine flow (from 0.05 ± 0.01 to 0.19 ± 0.03 ml/min) and Na+ excretion (from 0.87 ± 0.27 to 11.50 ± 6.13 μeq/min). Thus vagal mechanisms appear to play an important role in mediating excretion of Na+ and water in response to acute volume expansion in the conscious primate.
Original language | English (US) |
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Pages (from-to) | H546-H549 |
Journal | American Journal of Physiology - Heart and Circulatory Physiology |
Volume | 250 |
Issue number | 4 (19/4) |
DOIs | |
State | Published - 1986 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Physiology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)