Vaginocervical stimulation attenuates hindpaw shock-induced substance P release into spinal cord superfusates in rats

Judith L. Steinman, Stuart W. Hoffman, Cynthia Banas, Barry R. Komisaruk

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The present study was designed to elucidate the mechanism in the spinal cord by which vaginocervical stimulation (VS) attenuates responses to noxious stimulation. This was accomplished by testing the hypothesis that VS reduces noxious stimulation-induced release of substance P at the level of the spinal cord. Noxious foot shock significantly increased the release of substance P (measured using radioimmunoassay) into superfusates of the lumbosacral spinal cord region in urethane-anesthetized rats. VS applied concurrently with foot shock significantly attenuated the release of substance P compared to the foot shock-only condition. In addition, substance P levels were significantly lower after the VS-only condition than after the no stimulation or foot shock-only conditions. These findings indicate that VS may produce analgesia, at least in part, by suppressing the release of substance P within the spinal cord.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalBrain research
Volume647
Issue number2
DOIs
StatePublished - Jun 6 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Analgesia
  • Cervix
  • Pain
  • Spinal cord
  • Substance P
  • Vagina

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