Variation in ten lysosomal hydrolase enzyme activities in inbred mouse strains

William G. Johnson, Jacqueline L. Hong, Susan M. Knights

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Activities of 10 lysosomal hydrolase enzymes (β-hexosaminidase, β-galactosidase, α-galactosidase, α-mannosidase, β-mannosidase, α-l-fucosidase, β-glucuronidase, α-glucosidase, α-N-acetylgalactosaminidase, and acid phosphatase) were determined in eight organs (brain, liver, kidney, spleen, heart, skeletal muscle, lung, and testis) in males and females of six inbred mouse strains (C57 BL/6J, C3H/HeJ, DBA/2J, BALB/cJ, P/J, and 129/J). Examples of enzyme-specific variation, organ-specific variation, and enzyme- and organ-specific variation were found. New enzyme-specific variants with the features of systemic regulators for α-l-fucosidase and β-mannosidase were found. Known variants were detected. Organ-specific variants had some of the properties expected for a new class of genes affecting multiple enzymes: organ-specific regulators.

Original languageEnglish (US)
Pages (from-to)891-909
Number of pages19
JournalBiochemical Genetics
Issue number11-12
StatePublished - Dec 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics


  • inbred mice
  • lysosomal hydrolase enzyme
  • organ-specific regulator
  • regulatory gene
  • structural gene
  • systemic regulator


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