TY - GEN
T1 - Vascular autoregulation in a model using mechanosensory ion channels
AU - Craelius, William
PY - 1993
Y1 - 1993
N2 - Mechanosensory ion channels (MACs) are incorporated into a myogenic model, which states that blood flow is regulated, in part, through feedback regulation of vessel diameter, that is controlled by smooth muscles surrounding the afferent arterioles. Feedback to the smooth muscle effectors is provided by tension-dependent currents from MACs, consisting mainly of K+ efflux. Smooth muscles respond to depolarizing K+ currents by contraction. The model shows the ability of vascular beds to autoregulate flow in the presence of changing arterial pressures.
AB - Mechanosensory ion channels (MACs) are incorporated into a myogenic model, which states that blood flow is regulated, in part, through feedback regulation of vessel diameter, that is controlled by smooth muscles surrounding the afferent arterioles. Feedback to the smooth muscle effectors is provided by tension-dependent currents from MACs, consisting mainly of K+ efflux. Smooth muscles respond to depolarizing K+ currents by contraction. The model shows the ability of vascular beds to autoregulate flow in the presence of changing arterial pressures.
UR - http://www.scopus.com/inward/record.url?scp=0027192389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027192389&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0027192389
SN - 0780309251
T3 - Bioengineering, Proceedings of the Northeast Conference
SP - 21
EP - 27
BT - 1993 IEEE 19th Annual Northeasrt Bioengineering Conference
PB - Publ by IEEE
T2 - Proceedings of the 1993 IEEE 19th Annual Northeast Bioengineering Conference
Y2 - 18 March 1993 through 19 March 1993
ER -