Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease

Nicholas M. Tataryn, Vishal Singh, Jonathan P. Dyke, Hanna E. Berk-Rauch, Dana M. Clausen, Eric Aronowitz, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Vascular perturbations and cerebral hypometabolism are emerging as important components of Alzheimer's disease (AD). While various in vivo imaging modalities have been designed to detect changes of cerebral perfusion and metabolism in AD patients and animal models, study results were often heterogenous with respect to imaging techniques and animal models. We therefore evaluated cerebral perfusion and glucose metabolism of two popular transgenic AD mouse strains, TgCRND8 and 5xFAD, at 7 and 12 months-of-age under identical conditions and analyzed possible molecular mechanisms underlying heterogeneous cerebrovascular phenotypes. Results revealed disparate findings in these two strains, displaying important aspects of AD progression. TgCRND8 mice showed significantly decreased cerebral blood flow and glucose metabolism with unchanged cerebral blood volume (CBV) at 12 months-of-age whereas 5xFAD mice showed unaltered glucose metabolism with significant increase in CBV at 12 months-of-age and a biphasic pattern of early hypoperfusion followed by a rebound to normal cerebral blood flow in late disease. Finally, immunoblotting assays suggested that VEGF dependent vascular tone change may restore normoperfusion and increase CBV in 5xFAD.

Original languageEnglish (US)
Pages (from-to)96-108
Number of pages13
JournalNeurobiology of Aging
Volume107
DOIs
StatePublished - Nov 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

Keywords

  • Alzheimer disease
  • Arterial spin labeling (ASL)
  • Cerebral blood flow
  • Cerebral blood volume
  • Cerebral metabolism
  • Dynamic susceptibility contrast-enhanced magnetic resonance imaging
  • Vascular endothelial growth factor

Fingerprint

Dive into the research topics of 'Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease'. Together they form a unique fingerprint.

Cite this