Vasoactive intestinal polypeptide (VIP) potentiates the behavioral effect of substance P intrathecal administration

Carlos Beyer; Mario Caba; Cynthia Banas; Barry R. Komisaruk

doi:10.1016/0091-3057(91)90149-V

Vasoactive intestinal polypeptide (VIP) potentiates the behavioral effect of substance P intrathecal administration

Carlos Beyer, Mario Caba, Cynthia Banas, Barry R. Komisaruk

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Intrathecal (IT) injection of 20 μg substance P (SP) induced a behavioral syndrome consisting of scratching and biting the flanks (83% and 57%, respectively, of 48 rats), and distress-like vocalization (42% of 26 rats tested) in response to a previously innocuous tactile stimulus with a von Frey fiber (allodynia). These behavioral events following SP were of short latency (1-2 min) and duration (around 10 min). Injection IT of 5 μg, but not 1 μg, of vasoactive intestinal polypeptide (VIP), concurrently with SP, significantly increased the frequency of both scratching and biting bouts over that produced by SP alone. VIP IT alone (1 or 5 μg) did not stimulate scratching-biting, but induced allodynia in a significant proportion of rats.

Original language	English (US)
Pages (from-to)	695-698
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(91)90149-V
State	Published - Jul 1991

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Keywords

Allodynia
Biting
Females
Hyperalgesia
Itch
Pain
Rats
Scratching
Substance P
Vasoactive intestinal polypeptide

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title = "Vasoactive intestinal polypeptide (VIP) potentiates the behavioral effect of substance P intrathecal administration",

abstract = "Intrathecal (IT) injection of 20 μg substance P (SP) induced a behavioral syndrome consisting of scratching and biting the flanks (83% and 57%, respectively, of 48 rats), and distress-like vocalization (42% of 26 rats tested) in response to a previously innocuous tactile stimulus with a von Frey fiber (allodynia). These behavioral events following SP were of short latency (1-2 min) and duration (around 10 min). Injection IT of 5 μg, but not 1 μg, of vasoactive intestinal polypeptide (VIP), concurrently with SP, significantly increased the frequency of both scratching and biting bouts over that produced by SP alone. VIP IT alone (1 or 5 μg) did not stimulate scratching-biting, but induced allodynia in a significant proportion of rats.",

keywords = "Allodynia, Biting, Females, Hyperalgesia, Itch, Pain, Rats, Scratching, Substance P, Vasoactive intestinal polypeptide",

author = "Carlos Beyer and Mario Caba and Cynthia Banas and Komisaruk, {Barry R.}",

year = "1991",

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AU - Beyer, Carlos

AU - Caba, Mario

AU - Banas, Cynthia

AU - Komisaruk, Barry R.

PY - 1991/7

Y1 - 1991/7

N2 - Intrathecal (IT) injection of 20 μg substance P (SP) induced a behavioral syndrome consisting of scratching and biting the flanks (83% and 57%, respectively, of 48 rats), and distress-like vocalization (42% of 26 rats tested) in response to a previously innocuous tactile stimulus with a von Frey fiber (allodynia). These behavioral events following SP were of short latency (1-2 min) and duration (around 10 min). Injection IT of 5 μg, but not 1 μg, of vasoactive intestinal polypeptide (VIP), concurrently with SP, significantly increased the frequency of both scratching and biting bouts over that produced by SP alone. VIP IT alone (1 or 5 μg) did not stimulate scratching-biting, but induced allodynia in a significant proportion of rats.

AB - Intrathecal (IT) injection of 20 μg substance P (SP) induced a behavioral syndrome consisting of scratching and biting the flanks (83% and 57%, respectively, of 48 rats), and distress-like vocalization (42% of 26 rats tested) in response to a previously innocuous tactile stimulus with a von Frey fiber (allodynia). These behavioral events following SP were of short latency (1-2 min) and duration (around 10 min). Injection IT of 5 μg, but not 1 μg, of vasoactive intestinal polypeptide (VIP), concurrently with SP, significantly increased the frequency of both scratching and biting bouts over that produced by SP alone. VIP IT alone (1 or 5 μg) did not stimulate scratching-biting, but induced allodynia in a significant proportion of rats.

KW - Allodynia

KW - Biting

KW - Females

KW - Hyperalgesia

KW - Itch

KW - Pain

KW - Rats

KW - Scratching

KW - Substance P

KW - Vasoactive intestinal polypeptide

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