Vasoactive intestinal polypeptide (VIP) potentiates the behavioral effect of substance P intrathecal administration

Carlos Beyer, Mario Caba, Cynthia Banas, Barry R. Komisaruk

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Intrathecal (IT) injection of 20 μg substance P (SP) induced a behavioral syndrome consisting of scratching and biting the flanks (83% and 57%, respectively, of 48 rats), and distress-like vocalization (42% of 26 rats tested) in response to a previously innocuous tactile stimulus with a von Frey fiber (allodynia). These behavioral events following SP were of short latency (1-2 min) and duration (around 10 min). Injection IT of 5 μg, but not 1 μg, of vasoactive intestinal polypeptide (VIP), concurrently with SP, significantly increased the frequency of both scratching and biting bouts over that produced by SP alone. VIP IT alone (1 or 5 μg) did not stimulate scratching-biting, but induced allodynia in a significant proportion of rats.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume39
Issue number3
DOIs
StatePublished - Jul 1991

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Keywords

  • Allodynia
  • Biting
  • Females
  • Hyperalgesia
  • Itch
  • Pain
  • Rats
  • Scratching
  • Substance P
  • Vasoactive intestinal polypeptide

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