Vasopressin and neurophysin

High concentrations in monkey hypophyseal portal blood

Earl A. Zimmerman, Peter Carmel, M. Kazim Husain, Michel Ferin, Myron Tannenbaum, Andrew G. Frantz, Alan G. Robinson

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Vasopressin and its binding protein, neurophysin, were measured by radioimmunoassay in the hypophyseal portal blood of monkeys after cannulation of individual long portal veins. Mean vasopressin concentrations (13,800 picograms per milliliter) in portal blood were more than 300 times as high as those in the systemic circulation (42 picograms per milliliter). Neurophysin concentration was approximately 25 times as high in portal as in systemic blood. By immunoperoxidase techniques, high concentrations of neurophysin were demonstrated around portal capillaries of the median eminence. These studies indicate direct secretion of vasopressin and neurophysin into the portal circulation; the quantities secreted during stress may be sufficient to exert significant effects on secretion of anterior pituitary hormone.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalScience
Volume182
Issue number4115
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

Fingerprint

Neurophysins
Vasopressins
Haplorhini
Anterior Pituitary Hormones
Median Eminence
Portal Vein
Immunoenzyme Techniques
Catheterization
Radioimmunoassay
Carrier Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Zimmerman, E. A., Carmel, P., Husain, M. K., Ferin, M., Tannenbaum, M., Frantz, A. G., & Robinson, A. G. (1973). Vasopressin and neurophysin: High concentrations in monkey hypophyseal portal blood. Science, 182(4115), 925-927. https://doi.org/10.1126/science.182.4115.925
Zimmerman, Earl A. ; Carmel, Peter ; Husain, M. Kazim ; Ferin, Michel ; Tannenbaum, Myron ; Frantz, Andrew G. ; Robinson, Alan G. / Vasopressin and neurophysin : High concentrations in monkey hypophyseal portal blood. In: Science. 1973 ; Vol. 182, No. 4115. pp. 925-927.
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Zimmerman, EA, Carmel, P, Husain, MK, Ferin, M, Tannenbaum, M, Frantz, AG & Robinson, AG 1973, 'Vasopressin and neurophysin: High concentrations in monkey hypophyseal portal blood', Science, vol. 182, no. 4115, pp. 925-927. https://doi.org/10.1126/science.182.4115.925

Vasopressin and neurophysin : High concentrations in monkey hypophyseal portal blood. / Zimmerman, Earl A.; Carmel, Peter; Husain, M. Kazim; Ferin, Michel; Tannenbaum, Myron; Frantz, Andrew G.; Robinson, Alan G.

In: Science, Vol. 182, No. 4115, 01.01.1973, p. 925-927.

Research output: Contribution to journalArticle

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AU - Zimmerman, Earl A.

AU - Carmel, Peter

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AU - Robinson, Alan G.

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Zimmerman EA, Carmel P, Husain MK, Ferin M, Tannenbaum M, Frantz AG et al. Vasopressin and neurophysin: High concentrations in monkey hypophyseal portal blood. Science. 1973 Jan 1;182(4115):925-927. https://doi.org/10.1126/science.182.4115.925