Veno-ventricular interaction and heart failure

Gary Drzewiecki, Abraham Noordergraaf

Research output: Contribution to conferencePaperpeer-review


An analytical solution for ventricular preload is provided. The approach rests on basic principles of autoregulation of cardiac output and blood pressure by the kidney's control of total blood volume. A computer model of the left ventricle and afterload was developed that incorporates these mechanisms. For control conditions, it was found that the model converged to the preload necessary for the prescribed cardiac output and pressure. For a decrement in ventricular contractile properties, the model predicted an increase in total blood volume and preload. This compensatory response maintained ventricular output. These responses are consistent with observations of early cardiac failure.

Original languageEnglish (US)
Number of pages2
StatePublished - 2000
EventIEEE 26th Annual Northeast Bioengineering Conference - Sotrrs, CT, USA
Duration: Apr 8 2000Apr 9 2000


OtherIEEE 26th Annual Northeast Bioengineering Conference
CitySotrrs, CT, USA

All Science Journal Classification (ASJC) codes

  • Bioengineering


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