VIP-, enkephalin-, substance P- and somatostatin-like immunoreactivity in neurons intrinsic to the intestine: immunohistochemical evidence from organotypic tissue cultures

Marianne Schultzberg, Cheryl F. Dreyfus, Michael D. Gershon, Tomas Hökfelt, Robert P. Elde, Göran Nilsson, Sami Said, Menek Goldstein

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Small intestine from 18-day fetal mice grown for 3 weeks in organotypic tissue culture was found to contain numerous VIP, enkephalin, substance P and some somatostatin immunoreactive nerve fibers. Since these cultures should be devoid of all afferent or other extrinsic neuronal inputs, it is concluded that there are VIP, enkephalin, substance P and somatostatin containing neurons intrinsic to the intestinal wall. However, all 4 peptides may also be present in neurons originating outside the gastrointestinal tract as well as in the intrinsic neurons.

Original languageEnglish (US)
Pages (from-to)239-248
Number of pages10
JournalBrain research
Volume155
Issue number2
DOIs
StatePublished - Oct 27 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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