TY - JOUR
T1 - Virulence Factors in Hypervirulent Klebsiella pneumoniae
AU - Zhu, Jie
AU - Wang, Tao
AU - Chen, Liang
AU - Du, Hong
N1 - Funding Information:
This study was supported by Gusu Key Health Talent of Suzhou, the Jiangsu Youth Medical Talents Program (QN-867), Science Foundation of Jiangsu Province Health Department (ZDB2020014), the Science and Technology Program of Suzhou (SZS201715), and the Discipline Construction Program of the Second Affiliated Hospital of Soochow University (XKTJ-TD202001).
Publisher Copyright:
© Copyright © 2021 Zhu, Wang, Chen and Du.
PY - 2021/4/8
Y1 - 2021/4/8
N2 - Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.
AB - Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.
KW - Klebsiella pneumoniae
KW - capsule
KW - hypermucoviscous
KW - hypervirulence
KW - siderophores
KW - virulence factors
UR - http://www.scopus.com/inward/record.url?scp=85104639803&partnerID=8YFLogxK
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U2 - 10.3389/fmicb.2021.642484
DO - 10.3389/fmicb.2021.642484
M3 - Review article
AN - SCOPUS:85104639803
SN - 1664-302X
VL - 12
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 642484
ER -