Visual evoked potentials during thiopentone-fentanylnitrous oxide anaesthesia in humans

Oak Za Chi, Sarah Ryterband, Cristine Field

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Visual evoked potentials (VEP) during thiopentone-fentanylnitrous oxide anaesthesia were studied in 15 healthy patients undergoing non-neurosurgical procedures. The VEP was recorded before and at 1 and 2 min after induction of anaesthesia with 5-6 mg · kg-1 of thiopentone. After recording the 1 and 2 min VEPs, anaesthesia was maintained with a fentanylnitrous oxideoxygen combination, and further recordings were made at 5, 10, 15 and 20 min after induction. The 1 and 2 min VEPs showed a marked decrease in the amplitudes. Latencies were increased. The amplitudes gradually returned to the control level at 15 min, while the latencies remained increased throughout the study period. In conclusion, thiopentone should be avoided during the critical period of VEP recording. Once it is given, at least 15 min should elapse before an appropriate interpretation of the VEP can be made. Thiopentonefentanylnitrous oxide anaesthesia slightly increases the latencies of the VEP. These effects should be considered in the interpretation of the VEP when thiopentone-fentanylnitrous oxide anaesthesia is used.

Original languageEnglish (US)
Pages (from-to)637-640
Number of pages4
JournalCanadian Journal of Anaesthesia
Volume36
Issue number6
DOIs
StatePublished - Nov 1989

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Keywords

  • Anaesthetics, Gases: nitrous oxide
  • Anaesthetics, Intravenous: fentanyl, thiopentone
  • Brain: evoked potentials
  • Monitoring: evoked potentials, visual

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