Visualization of macromolecular structures

Seán I. O’Donoghue, David S. Goodsell, Achilleas S. Frangakis, Fabrice Jossinet, Roman A. Laskowski, Michael Nilges, Helen R. Saibil, Andrea Schafferhans, Rebecca C. Wade, Eric Westhof, Arthur J. Olson

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations


Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

Original languageEnglish (US)
Pages (from-to)1427
Number of pages1
JournalNature Methods
Issue number3
StatePublished - Mar 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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