Visualization of macromolecular structures

Seán I. O’Donoghue; David S. Goodsell; Achilleas S. Frangakis; Fabrice Jossinet; Roman A. Laskowski; Michael Nilges; Helen R. Saibil; Andrea Schafferhans; Rebecca C. Wade; Eric Westhof; Arthur J. Olson

doi:10.1038/nmeth.1427

Visualization of macromolecular structures

Seán I. O’Donoghue, David S. Goodsell, Achilleas S. Frangakis, Fabrice Jossinet, Roman A. Laskowski, Michael Nilges, Helen R. Saibil, Andrea Schafferhans, Rebecca C. Wade, Eric Westhof, Arthur J. Olson

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

Original language	English (US)
Pages (from-to)	1427
Number of pages	1
Journal	Nature Methods
Volume	7
Issue number	3
DOIs	https://doi.org/10.1038/nmeth.1427
State	Published - Mar 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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10.1038/nmeth.1427

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title = "Visualization of macromolecular structures",

abstract = "Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.",

author = "O{\textquoteright}Donoghue, {Se{\'a}n I.} and Goodsell, {David S.} and Frangakis, {Achilleas S.} and Fabrice Jossinet and Laskowski, {Roman A.} and Michael Nilges and Saibil, {Helen R.} and Andrea Schafferhans and Wade, {Rebecca C.} and Eric Westhof and Olson, {Arthur J.}",

note = "Funding Information: Thanks to M. Berynskyy and L. Biedermannova for assistance with Figure 6. This work was partly supported by the European Union Framework Programme 6 grant {\textquoteleft}TAMAHUD{\textquoteright} (LSHC-CT-2007-037472). R.C.W. gratefully acknowledges the support of the Klaus Tschira Foundation.",

year = "2010",

month = mar,

doi = "10.1038/nmeth.1427",

language = "English (US)",

volume = "7",

pages = "1427",

journal = "Nature Methods",

issn = "1548-7091",

publisher = "Nature Publishing Group",

number = "3",

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TY - JOUR

T1 - Visualization of macromolecular structures

AU - O’Donoghue, Seán I.

AU - Goodsell, David S.

AU - Frangakis, Achilleas S.

AU - Jossinet, Fabrice

AU - Laskowski, Roman A.

AU - Nilges, Michael

AU - Saibil, Helen R.

AU - Schafferhans, Andrea

AU - Wade, Rebecca C.

AU - Westhof, Eric

AU - Olson, Arthur J.

N1 - Funding Information: Thanks to M. Berynskyy and L. Biedermannova for assistance with Figure 6. This work was partly supported by the European Union Framework Programme 6 grant ‘TAMAHUD’ (LSHC-CT-2007-037472). R.C.W. gratefully acknowledges the support of the Klaus Tschira Foundation.

PY - 2010/3

Y1 - 2010/3

N2 - Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

AB - Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

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DO - 10.1038/nmeth.1427

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SN - 1548-7091

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SP - 1427

JO - Nature Methods

JF - Nature Methods

IS - 3

ER -

Visualization of macromolecular structures

Abstract

All Science Journal Classification (ASJC) codes

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