Vitamin A and β-carotene in pregnant and breastfeeding post-bariatric women in an urban population

Diana Garretto, Youn Kyung Kim, Loredana Quadro, Rebekah R. Rhodas, Veronica Pimentel, Natalie A. Crnosija, Lizhou Nie, Peter Bernstein, Pamela Tropper, Genevieve S. Neal-Perry

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Abstract

As breastfeeding awareness and social acceptance are increased, maternal nutritional deficiency requires more investigation. A prospective cohort study was conducted to determine if vitamin A deficiency is more common in pregnant, lactating post-bariatric surgery women in an inner city population. Antepartum, women after bariatric surgery and controls with no history of malabsorption were recruited. Third trimester, postpartum maternal blood and cord blood were collected as well as three breast milk samples: colostrum, transitional and mature milk. A nutritional survey of diet was completed. Each serum sample was analyzed for total retinol and β-carotene; breast milk samples were analyzed for retinol and retinyl esters, total retinol and β-carotene. Fifty-three women after bariatric surgery and 66 controls were recruited. Postpartum serum retinol was significantly higher in women after bariatric surgery in the univariate analysis (P<0.0001) and confirmed in the multiple linear mixed model (P=0.0001). Breast milk colostrum retinol and transitional milk total retinol were significantly greater in the bariatric surgery group in the univariate analysis (P=0.03 and P=0.02, respectively), but not after adjusting for confounders. Serum β-carotene in the third trimester and postpartum were lower (P<0.0001 and P=0.003, respectively) in the bariatric surgery group but not after adjusting for confounders. Vitamin A deficiency was high in both groups in serum and breast milk samples. Nutritional deficiencies in breastfeeding women after bariatric surgeries may in fact be less common than in control women in an inner city.

Original languageEnglish (US)
JournalJournal of Perinatal Medicine
DOIs
Publication statusAccepted/In press - Jan 1 2018

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Keywords

  • bariatric surgery
  • breast milk
  • nutrition
  • pregnancy
  • vitamin A
  • vitamin A deficiency
  • β-carotene

Cite this

Garretto, D., Kim, Y. K., Quadro, L., Rhodas, R. R., Pimentel, V., Crnosija, N. A., ... Neal-Perry, G. S. (Accepted/In press). Vitamin A and β-carotene in pregnant and breastfeeding post-bariatric women in an urban population. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2018-0142