Vitamin C as a radioprotector against iodine-131 in vivo

V. R. Narra, R. W. Howell, K. S.R. Sastry, D. V. Rao

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The capacity of vitamin C (ascorbic acid) to mitigate radiation damage resulting from the tissue-incorporated radionuclide 131I is examined. Spermatogenesis in mice is the experimental model and spermhead survival is the biological endpoint. When a small nontoxic amount of vitamin C was injected, followed by a similar injection of 131I, the 37% spermhead survival dose (D37) increased by a factor of 2.2 compared with the D37 in animals receiving only the radionuclide. Similar radioprotection was also observed when the animals were maintained on a diet enriched with 1% vitamin C (by weight). These results suggest that vitamin C may play an important role as a radioprotector against accidental or medical radiation exposures, especially when radionuclides are incorporated in the body and deliver the dose in a chronic fashion.

Original languageEnglish (US)
Pages (from-to)637-640
Number of pages4
JournalJournal of Nuclear Medicine
Issue number4
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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