Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability

Amanda Costa Caritá, Bruno Fonseca-Santos, Jemima Daniela Shultz, Bozena Michniak-Kohn, Marlus Chorilli, Gislaine Ricci Leonardi

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.

Original languageEnglish (US)
Article number102117
JournalNanomedicine: Nanotechnology, Biology, and Medicine
StatePublished - Feb 2020

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science


  • Ascorbic acid
  • Drug delivery
  • Liposomes
  • Microemulsions
  • Nanoparticles
  • Targeting


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