Vitamin D and the intestine: Review and update

Sylvia Christakos; Shanshan Li; Jessica De La Cruz; Noah F. Shroyer; Zachary K. Criss; Michael P. Verzi; James C. Fleet

doi:10.1016/j.jsbmb.2019.105501

Vitamin D and the intestine: Review and update

Sylvia Christakos, Shanshan Li, Jessica De La Cruz, Noah F. Shroyer, Zachary K. Criss, Michael P. Verzi, James C. Fleet

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)₂D₃ action in the intestine and highlighting the importance of 1,25(OH)₂D₃ action across the proximal/distal and crypt/villus axes in the intestine is summarized.

Original language	English (US)
Article number	105501
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	196
DOIs	https://doi.org/10.1016/j.jsbmb.2019.105501
State	Published - Feb 2020

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

Keywords

1,25-dihydroxyvitamin D3
Calbindin-D
Crypt, SLC30A10
Intestine
Plasma membrane calcium pump PMCA1b
Transient receptor potential vanilloid type-6
Villus

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10.1016/j.jsbmb.2019.105501

Cite this

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title = "Vitamin D and the intestine: Review and update",

abstract = "The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)2D3 action in the intestine and highlighting the importance of 1,25(OH)2D3 action across the proximal/distal and crypt/villus axes in the intestine is summarized.",

keywords = "1,25-dihydroxyvitamin D3, Calbindin-D, Crypt, SLC30A10, Intestine, Plasma membrane calcium pump PMCA1b, Transient receptor potential vanilloid type-6, Villus",

author = "Sylvia Christakos and Shanshan Li and {De La Cruz}, Jessica and Shroyer, {Noah F.} and Criss, {Zachary K.} and Verzi, {Michael P.} and Fleet, {James C.}",

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year = "2020",

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language = "English (US)",

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journal = "Journal of Steroid Biochemistry and Molecular Biology",

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T2 - Review and update

AU - Christakos, Sylvia

AU - Li, Shanshan

AU - De La Cruz, Jessica

AU - Shroyer, Noah F.

AU - Criss, Zachary K.

AU - Verzi, Michael P.

AU - Fleet, James C.

PY - 2020/2

Y1 - 2020/2

N2 - The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)2D3 action in the intestine and highlighting the importance of 1,25(OH)2D3 action across the proximal/distal and crypt/villus axes in the intestine is summarized.

AB - The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)2D3 action in the intestine and highlighting the importance of 1,25(OH)2D3 action across the proximal/distal and crypt/villus axes in the intestine is summarized.

KW - 1,25-dihydroxyvitamin D3

KW - Calbindin-D

KW - Crypt, SLC30A10

KW - Intestine

KW - Plasma membrane calcium pump PMCA1b

KW - Transient receptor potential vanilloid type-6

KW - Villus

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JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

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ER -

Vitamin D and the intestine: Review and update

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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