Vitamin D and the intestine: Review and update

Sylvia Christakos, Shanshan Li, Jessica De La Cruz, Noah F. Shroyer, Zachary K. Criss, Michael P. Verzi, James C. Fleet

Research output: Contribution to journalReview article


The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)2D3 action in the intestine and highlighting the importance of 1,25(OH)2D3 action across the proximal/distal and crypt/villus axes in the intestine is summarized.

Original languageEnglish (US)
Article number105501
JournalJournal of Steroid Biochemistry and Molecular Biology
StatePublished - Feb 2020

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology


  • 1,25-dihydroxyvitamin D3
  • Calbindin-D
  • Crypt, SLC30A10
  • Intestine
  • Plasma membrane calcium pump PMCA1b
  • Transient receptor potential vanilloid type-6
  • Villus

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