Vitamin D biology revealed through the study of knockout and transgenic mouse models

Sylvia Christakos, Tanya Seth, Jennifer Hirsch, Angela Porta, Anargyros Moulas, Puneet Dhawan

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Early studies identifying vitamin D as an antirachitic factor led to studies in vitamin D-deficient models that resulted in a basic understanding of the mechanism of action of vitamin D. Recent studies using genetically modified mice have provided important new insight into the physiological role of vitamin D at target tissues and the functional significance of vitamin D target proteins, as well as the functional significance of proteins involved in the transport and metabolism of vitamin D. Studies using these mice have played an increasingly important role in elucidating the mechanisms involved in the control of calcium homeostasis and have provided evidence for a role of vitamin D in extraskeletal health.

Original languageEnglish (US)
Pages (from-to)71-85
Number of pages15
JournalAnnual Review of Nutrition
StatePublished - Jul 2013

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


  • 1,25-dihydroxyvitamin D3
  • 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1)
  • 25-hydroxyvitamin D3-1-α-hydroxylase (CYP27B1)
  • Calbindin-D9k
  • Klotho
  • Transient receptor potential vanilloid type 5 (TRPV5)
  • Transient receptor potential vanilloid type 6 (TRPV6)


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