Vitamin D gene regulation

Sylvia Christakos; J. Wesley Pike

doi:10.1016/B978-0-12-814841-9.00030-0

Vitamin D gene regulation

Sylvia Christakos, J. Wesley Pike

New Jersey Medical School (NJMS), Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Vitamin D is a principal factor required for the development and maintenance of bone as well as for maintaining normal calcium and phosphorus homeostasis. In addition, evidence has indicated the involvement of vitamin D in a number of diverse cellular processes including effects on differentiation and cell proliferation, cancer progression and on the immune system. In this chapter we review vitamin D metabolism (including recent advances obtained from the identification of clinical syndromes related to abnormalities in vitamin D metabolism) and action with a focus on vitamin D action in classical target tissues. In addition, recent studies using genome-wide techniques are reviewed which provide new concepts and novel insight into the mechanisms of 1,25(OH)₂D₃ action.

Original language	English (US)
Title of host publication	Principles of Bone Biology
Publisher	Elsevier
Pages	739-756
Number of pages	18
ISBN (Electronic)	9780128148419
DOIs	https://doi.org/10.1016/B978-0-12-814841-9.00030-0
State	Published - Jan 1 2019

All Science Journal Classification (ASJC) codes

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Keywords

Bone development
ChIP sequencing
Chromatin immunoprecipitation
Gene regulation
Metabolism
Vitamin D
Vitamin D receptor

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10.1016/B978-0-12-814841-9.00030-0

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AB - Vitamin D is a principal factor required for the development and maintenance of bone as well as for maintaining normal calcium and phosphorus homeostasis. In addition, evidence has indicated the involvement of vitamin D in a number of diverse cellular processes including effects on differentiation and cell proliferation, cancer progression and on the immune system. In this chapter we review vitamin D metabolism (including recent advances obtained from the identification of clinical syndromes related to abnormalities in vitamin D metabolism) and action with a focus on vitamin D action in classical target tissues. In addition, recent studies using genome-wide techniques are reviewed which provide new concepts and novel insight into the mechanisms of 1,25(OH)2D3 action.

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KW - ChIP sequencing

KW - Chromatin immunoprecipitation

KW - Gene regulation

KW - Metabolism

KW - Vitamin D

KW - Vitamin D receptor

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Vitamin D gene regulation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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