Vitamin D gene regulation

Sylvia Christakos, J. Wesley Pike

Research output: Chapter in Book/Report/Conference proceedingChapter


Vitamin D is a principal factor required for the development and maintenance of bone as well as for maintaining normal calcium and phosphorus homeostasis. In addition, evidence has indicated the involvement of vitamin D in a number of diverse cellular processes including effects on differentiation and cell proliferation, cancer progression and on the immune system. In this chapter we review vitamin D metabolism (including recent advances obtained from the identification of clinical syndromes related to abnormalities in vitamin D metabolism) and action with a focus on vitamin D action in classical target tissues. In addition, recent studies using genome-wide techniques are reviewed which provide new concepts and novel insight into the mechanisms of 1,25(OH)2D3 action.

Original languageEnglish (US)
Title of host publicationPrinciples of Bone Biology
Number of pages18
ISBN (Electronic)9780128148419
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


  • Bone development
  • ChIP sequencing
  • Chromatin immunoprecipitation
  • Gene regulation
  • Metabolism
  • Vitamin D
  • Vitamin D receptor


Dive into the research topics of 'Vitamin D gene regulation'. Together they form a unique fingerprint.

Cite this