Vitamin D: Metabolism

Sylvia Christakos; Dare V. Ajibade; Puneet Dhawan; Adam J. Fechner; Leila J. Mady

doi:10.1016/j.rdc.2012.03.003

Vitamin D: Metabolism

Sylvia Christakos, Dare V. Ajibade, Puneet Dhawan, Adam J. Fechner, Leila J. Mady

New Jersey Medical School (NJMS), Biochemistry

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

The biologically active metabolite of vitamin D, 1,25(OH) ₂D ₃, affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH) ₂D ₃. The role of extrarenal 1α(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Rheumatic Disease Clinics of North America
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.rdc.2012.03.003
State	Published - Feb 2012

All Science Journal Classification (ASJC) codes

Rheumatology

Keywords

FGF23
Kidney
Placenta
Vitamin D binding protein
Vitamin D hydroxylases
Vitamin D metabolites

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10.1016/j.rdc.2012.03.003

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title = "Vitamin D: Metabolism",

abstract = "The biologically active metabolite of vitamin D, 1,25(OH) 2D 3, affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH) 2D 3. The role of extrarenal 1α(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.",

keywords = "FGF23, Kidney, Placenta, Vitamin D binding protein, Vitamin D hydroxylases, Vitamin D metabolites",

author = "Sylvia Christakos and Ajibade, {Dare V.} and Puneet Dhawan and Fechner, {Adam J.} and Mady, {Leila J.}",

note = "Funding Information: Studies referenced from the laboratory of S.C. were supported in part by NIH grant DK-38961-21 . ",

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T2 - Metabolism

AU - Christakos, Sylvia

AU - Ajibade, Dare V.

AU - Dhawan, Puneet

AU - Fechner, Adam J.

AU - Mady, Leila J.

N1 - Funding Information: Studies referenced from the laboratory of S.C. were supported in part by NIH grant DK-38961-21 .

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AB - The biologically active metabolite of vitamin D, 1,25(OH) 2D 3, affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH) 2D 3. The role of extrarenal 1α(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.

KW - FGF23

KW - Kidney

KW - Placenta

KW - Vitamin D binding protein

KW - Vitamin D hydroxylases

KW - Vitamin D metabolites

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JO - Rheumatic Disease Clinics of North America

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Vitamin D: Metabolism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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