Vitamin D modulates airway smooth muscle function in COPD

Audreesh Banerjee, Reynold Panettieri

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

COPD is a disease manifested as persistent airflow obstruction with an enhanced inflammatory response in the airways and lungs to noxious particles and gases which evokes symptoms of dyspnea on exertion, cough and mucus production. Airway smooth muscle plays a central role in the COPD diathesis and is implicated in many aspects of COPD pathogenesis. Vitamin D deficiency has been associated with COPD severity and studies suggest a role for Vitamin D as a treatment for COPD. In this review, we describe the effects of 1,25-dihydroxyvitamin D on airway smooth muscle function, including agonist-induced shortening, secretion of inflammatory mediators, and myocyte hypertrophy and hyperplasia.

Original languageEnglish (US)
Pages (from-to)266-274
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume12
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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