Vitamins A, C, and e May Reduce Intestinal 210Po Levels after Ingestion

Francis W. Kemp, Frank Portugal, John M. Akudugu, Prasad V.S.V. Neti, Ronaldo P. Ferraris, Roger W. Howell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Damage to the gut mucosa is a probable contributory cause of death from ingested 210Po. Therefore, medical products are needed that can prevent, mitigate, and/or repair gastrointestinal (GI) damage caused by high-LET radiation emitted by 210Po. The present studies investigated the capacity of a diet highly enriched with vitamins A, C, and E (vitamin ACE) to protect against intestinal mucosal damage indicated by functional reductions in nutrient transport caused by orally ingested 210Po. Mice were gavaged with 0 or 18.5 kBq 210Po-citrate and fed a control or vitamin ACE-enriched diet (the latter beginning either 96 h before or immediately after gavage). Mouse intestines significantly retained 210Po on day 8 post-gavage. The concentration of 210Po in intestinal tissues was significantly (p<0.05) lower in all vitamin ACE groups compared to control. There were borderline significant 210Po-induced reductions in intestinal absorption of D-fructose. The combination of vitamins A, C, and E may reduce 210Po incorporation in the intestines when given before, or enhance decorporation when provided after, 210Po gavage.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalHealth physics
Volume111
Issue number1
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Keywords

  • Po
  • adsorption
  • biokinetics
  • contamination
  • internal

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