Voltage dependence of junctional conductance in early amphibian embryos

D. C. Spray; A. L. Harris; M. V.L. Bennett

doi:10.1126/science.312530

Voltage dependence of junctional conductance in early amphibian embryos

D. C. Spray, A. L. Harris, M. V.L. Bennett

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Isolated pairs of blastomeres from early amphibian embryos (Ambystoma, Rana, Xenopus) are electrotonically coupled. Junctional conductance and permeability to the dye Lucifer Yellow are markedly and reversibly decreased by moderate transjunctional polarization in either direction. The relationship between junctional conductance and transjunctional voltage is sufficiently steep that a physiological role in regulation of intercellular communication is plausible.

Original language	English (US)
Pages (from-to)	432-434
Number of pages	3
Journal	Science
Volume	204
Issue number	4391
DOIs	https://doi.org/10.1126/science.312530
State	Published - 1979
Externally published	Yes

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title = "Voltage dependence of junctional conductance in early amphibian embryos",

abstract = "Isolated pairs of blastomeres from early amphibian embryos (Ambystoma, Rana, Xenopus) are electrotonically coupled. Junctional conductance and permeability to the dye Lucifer Yellow are markedly and reversibly decreased by moderate transjunctional polarization in either direction. The relationship between junctional conductance and transjunctional voltage is sufficiently steep that a physiological role in regulation of intercellular communication is plausible.",

author = "Spray, {D. C.} and Harris, {A. L.} and Bennett, {M. V.L.}",

year = "1979",

doi = "10.1126/science.312530",

language = "English (US)",

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pages = "432--434",

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T1 - Voltage dependence of junctional conductance in early amphibian embryos

AU - Spray, D. C.

AU - Harris, A. L.

AU - Bennett, M. V.L.

PY - 1979

Y1 - 1979

N2 - Isolated pairs of blastomeres from early amphibian embryos (Ambystoma, Rana, Xenopus) are electrotonically coupled. Junctional conductance and permeability to the dye Lucifer Yellow are markedly and reversibly decreased by moderate transjunctional polarization in either direction. The relationship between junctional conductance and transjunctional voltage is sufficiently steep that a physiological role in regulation of intercellular communication is plausible.

AB - Isolated pairs of blastomeres from early amphibian embryos (Ambystoma, Rana, Xenopus) are electrotonically coupled. Junctional conductance and permeability to the dye Lucifer Yellow are markedly and reversibly decreased by moderate transjunctional polarization in either direction. The relationship between junctional conductance and transjunctional voltage is sufficiently steep that a physiological role in regulation of intercellular communication is plausible.

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U2 - 10.1126/science.312530

DO - 10.1126/science.312530

M3 - Article

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JO - Science

JF - Science

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ER -

Voltage dependence of junctional conductance in early amphibian embryos

Abstract

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