Water soluble polymers in tumor targeted delivery

J. Kopeček; P. Kopečková; T. Minko; Z. R. Lu; C. M. Peterson

doi:10.1016/S0168-3659(01)00330-3

Water soluble polymers in tumor targeted delivery

J. Kopeček, P. Kopečková, T. Minko, Z. R. Lu, C. M. Peterson

Research output: Contribution to journal › Article › peer-review

215 Scopus citations

Abstract

The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.

Original language	English (US)
Pages (from-to)	147-158
Number of pages	12
Journal	Journal of Controlled Release
Volume	74
Issue number	1-3
DOIs	https://doi.org/10.1016/S0168-3659(01)00330-3
State	Published - Jul 6 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Antibody fragments
Combination therapy
HPMA copolymers
Long-circulating macromolecular therapeutics
Ovarian carcinoma
PK1
Photodynamic therapy

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title = "Water soluble polymers in tumor targeted delivery",

abstract = "The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.",

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T1 - Water soluble polymers in tumor targeted delivery

AU - Kopeček, J.

AU - Kopečková, P.

AU - Minko, T.

AU - Lu, Z. R.

AU - Peterson, C. M.

PY - 2001/7/6

Y1 - 2001/7/6

N2 - The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.

AB - The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.

KW - Antibody fragments

KW - Combination therapy

KW - HPMA copolymers

KW - Long-circulating macromolecular therapeutics

KW - Ovarian carcinoma

KW - PK1

KW - Photodynamic therapy

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