Water soluble polymers in tumor targeted delivery

J. Kopeček, P. Kopečková, T. Minko, Z. R. Lu, C. M. Peterson

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.

Original languageEnglish (US)
Pages (from-to)147-158
Number of pages12
JournalJournal of Controlled Release
Volume74
Issue number1-3
DOIs
StatePublished - Jul 6 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Antibody fragments
  • Combination therapy
  • HPMA copolymers
  • Long-circulating macromolecular therapeutics
  • Ovarian carcinoma
  • PK1
  • Photodynamic therapy

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