Wavelet analysis of DNA walks

Adrian D. Haimovich, Bruce Byrne, Ramakrishna Ramaswamy, William J. Welsh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A wavelet transform of the DNA "walk" constructed from a genomic sequence offers a direct visualization of short and long-range patterns in nucleotide sequences. We study sequences that encode diverse biological functions, taken from a variety of genomes. Pattern irregularities in the transform are frequently associated with sequences of biological interest. Exonic regions, for example, visualize differently under wavelet analysis than introns, and ribosomal RNA regions display distinct universal signatures. DNA walk wavelet analysis can provide a sensitive and rapid assessment of the putative biological significance of genomic DNA.

Original languageEnglish (US)
Pages (from-to)1289-1298
Number of pages10
JournalJournal of Computational Biology
Volume13
Issue number7
DOIs
StatePublished - Sep 1 2006

Fingerprint

Wavelet Analysis
Wavelet analysis
Walk
DNA
Genomics
Ribosomal RNA
Nucleotides
Introns
Wavelet transforms
Irregularity
Visualization
Genes
Genome
Wavelet Transform
Signature
Transform
Distinct
Range of data

All Science Journal Classification (ASJC) codes

  • Modeling and Simulation
  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics

Keywords

  • DNA walk
  • Genomic analysis
  • Sequence analysis
  • Wavelet transform

Cite this

Haimovich, Adrian D. ; Byrne, Bruce ; Ramaswamy, Ramakrishna ; Welsh, William J. / Wavelet analysis of DNA walks. In: Journal of Computational Biology. 2006 ; Vol. 13, No. 7. pp. 1289-1298.
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Haimovich, AD, Byrne, B, Ramaswamy, R & Welsh, WJ 2006, 'Wavelet analysis of DNA walks', Journal of Computational Biology, vol. 13, no. 7, pp. 1289-1298. https://doi.org/10.1089/cmb.2006.13.1289

Wavelet analysis of DNA walks. / Haimovich, Adrian D.; Byrne, Bruce; Ramaswamy, Ramakrishna; Welsh, William J.

In: Journal of Computational Biology, Vol. 13, No. 7, 01.09.2006, p. 1289-1298.

Research output: Contribution to journalArticle

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