White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living with and without HIV

Carrie D. Johnston; Donald R. Hoover; Qiuhu Shi; Anjali Sharma; David B. Hanna; Kathryn Anastos; Phyllis C. Tien; Margaret Fischl; Deborah Gustafson; Amanda Spence; Roksana Karim; Audrey French; Michael Schneider; Adaora A. Adimora; Caitlin Moran; Deborah Konkle-Parker; Marshall J. Glesby

doi:10.1089/aid.2019.0174

White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living with and without HIV

Carrie D. Johnston, Donald R. Hoover, Qiuhu Shi, Anjali Sharma, David B. Hanna, Kathryn Anastos, Phyllis C. Tien, Margaret Fischl, Deborah Gustafson, Amanda Spence, Roksana Karim, Audrey French, Michael Schneider, Adaora A. Adimora, Caitlin Moran, Deborah Konkle-Parker, Marshall J. Glesby

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Diabetes mellitus (DM) is associated with expansion of proinflammatory lymphocyte subsets. We investigated the relationship of total white blood cell (WBC) count and lymphocyte subsets with incident DM in the Women's Interagency HIV Study (WIHS). Higher CD4 and CD8 T cell counts, lymphocyte count, and total WBC count were associated with incident DM among both women with and without HIV, although the association of CD8 was not statistically significant among women without HIV.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	AIDS research and human retroviruses
Volume	36
Issue number	2
DOIs	https://doi.org/10.1089/aid.2019.0174
State	Published - Feb 2020

All Science Journal Classification (ASJC) codes

Immunology
Virology
Infectious Diseases

Keywords

CD4
CD8
HIV-1
diabetes mellitus
lymphocyte
white blood cell
women

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10.1089/aid.2019.0174

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Johnston, C. D., Hoover, D. R., Shi, Q., Sharma, A., Hanna, D. B., Anastos, K., Tien, P. C., Fischl, M., Gustafson, D., Spence, A., Karim, R., French, A., Schneider, M., Adimora, A. A., Moran, C., Konkle-Parker, D., & Glesby, M. J. (2020). White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living with and without HIV. AIDS research and human retroviruses, 36(2), 131-133. https://doi.org/10.1089/aid.2019.0174

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abstract = "Diabetes mellitus (DM) is associated with expansion of proinflammatory lymphocyte subsets. We investigated the relationship of total white blood cell (WBC) count and lymphocyte subsets with incident DM in the Women's Interagency HIV Study (WIHS). Higher CD4 and CD8 T cell counts, lymphocyte count, and total WBC count were associated with incident DM among both women with and without HIV, although the association of CD8 was not statistically significant among women without HIV.",

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Johnston, CD, Hoover, DR, Shi, Q, Sharma, A, Hanna, DB, Anastos, K, Tien, PC, Fischl, M, Gustafson, D, Spence, A, Karim, R, French, A, Schneider, M, Adimora, AA, Moran, C, Konkle-Parker, D & Glesby, MJ 2020, 'White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living with and without HIV', AIDS research and human retroviruses, vol. 36, no. 2, pp. 131-133. https://doi.org/10.1089/aid.2019.0174

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AU - Johnston, Carrie D.

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Sharma, Anjali

AU - Hanna, David B.

AU - Anastos, Kathryn

AU - Tien, Phyllis C.

AU - Fischl, Margaret

AU - Gustafson, Deborah

AU - Spence, Amanda

AU - Karim, Roksana

AU - French, Audrey

AU - Schneider, Michael

AU - Adimora, Adaora A.

AU - Moran, Caitlin

AU - Konkle-Parker, Deborah

AU - Glesby, Marshall J.

PY - 2020/2

Y1 - 2020/2

N2 - Diabetes mellitus (DM) is associated with expansion of proinflammatory lymphocyte subsets. We investigated the relationship of total white blood cell (WBC) count and lymphocyte subsets with incident DM in the Women's Interagency HIV Study (WIHS). Higher CD4 and CD8 T cell counts, lymphocyte count, and total WBC count were associated with incident DM among both women with and without HIV, although the association of CD8 was not statistically significant among women without HIV.

AB - Diabetes mellitus (DM) is associated with expansion of proinflammatory lymphocyte subsets. We investigated the relationship of total white blood cell (WBC) count and lymphocyte subsets with incident DM in the Women's Interagency HIV Study (WIHS). Higher CD4 and CD8 T cell counts, lymphocyte count, and total WBC count were associated with incident DM among both women with and without HIV, although the association of CD8 was not statistically significant among women without HIV.

KW - CD4

KW - CD8

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KW - diabetes mellitus

KW - lymphocyte

KW - white blood cell

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White Blood Cell Counts, Lymphocyte Subsets, and Incident Diabetes Mellitus in Women Living with and without HIV

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All Science Journal Classification (ASJC) codes

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