Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in watanabe heritable hyperlipidemic versus new zealand white rabbits

Michael Kinter; Candy S. Robinson; Lisa C. Grimminger; Peter J. Gillies; Edward J. Shimshick; Carlos Ayers

doi:10.1006/bbrc.1994.1280

Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in watanabe heritable hyperlipidemic versus new zealand white rabbits

Michael Kinter, Candy S. Robinson, Lisa C. Grimminger, Peter J. Gillies, Edward J. Shimshick, Carlos Ayers

School of Environmental and Biological Sciences, Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Both plasma and whole blood concentrations of 4-hydroxy-2-nonenal (4HNE) were significantly elevated in a population (n = 6) of 2 year old Watanabe heritable hyperlipidemic rabbits relative to a population (n = 6) of New Zealand White rabbits. The plasma concentrations were 74 ± 10 nmol/L for the Watanabe group and 47 ± 6 nmol/L for the New Zealand White group. The whole blood concentrations were 364 ± 55 nmol/L for the Watanabe group and 188 ± 64 nmol/L for the New Zealand White group. These results indicate that 4HNE concentrations in blood can be elevated in individuals with atherosclerosis and demonstrate the potential link between the formation of 4HNE and the progression of atherosclerosis.

Original language	English (US)
Pages (from-to)	671-675
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	199
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.1280
State	Published - Mar 15 1994

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.1994.1280

Cite this

@article{fcec1ef0e27840d1a35c2240982bf4a8,

title = "Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in watanabe heritable hyperlipidemic versus new zealand white rabbits",

abstract = "Both plasma and whole blood concentrations of 4-hydroxy-2-nonenal (4HNE) were significantly elevated in a population (n = 6) of 2 year old Watanabe heritable hyperlipidemic rabbits relative to a population (n = 6) of New Zealand White rabbits. The plasma concentrations were 74 ± 10 nmol/L for the Watanabe group and 47 ± 6 nmol/L for the New Zealand White group. The whole blood concentrations were 364 ± 55 nmol/L for the Watanabe group and 188 ± 64 nmol/L for the New Zealand White group. These results indicate that 4HNE concentrations in blood can be elevated in individuals with atherosclerosis and demonstrate the potential link between the formation of 4HNE and the progression of atherosclerosis.",

author = "Michael Kinter and Robinson, {Candy S.} and Grimminger, {Lisa C.} and Gillies, {Peter J.} and Shimshick, {Edward J.} and Carlos Ayers",

year = "1994",

month = mar,

day = "15",

doi = "10.1006/bbrc.1994.1280",

language = "English (US)",

volume = "199",

pages = "671--675",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in watanabe heritable hyperlipidemic versus new zealand white rabbits

AU - Kinter, Michael

AU - Robinson, Candy S.

AU - Grimminger, Lisa C.

AU - Gillies, Peter J.

AU - Shimshick, Edward J.

AU - Ayers, Carlos

PY - 1994/3/15

Y1 - 1994/3/15

N2 - Both plasma and whole blood concentrations of 4-hydroxy-2-nonenal (4HNE) were significantly elevated in a population (n = 6) of 2 year old Watanabe heritable hyperlipidemic rabbits relative to a population (n = 6) of New Zealand White rabbits. The plasma concentrations were 74 ± 10 nmol/L for the Watanabe group and 47 ± 6 nmol/L for the New Zealand White group. The whole blood concentrations were 364 ± 55 nmol/L for the Watanabe group and 188 ± 64 nmol/L for the New Zealand White group. These results indicate that 4HNE concentrations in blood can be elevated in individuals with atherosclerosis and demonstrate the potential link between the formation of 4HNE and the progression of atherosclerosis.

AB - Both plasma and whole blood concentrations of 4-hydroxy-2-nonenal (4HNE) were significantly elevated in a population (n = 6) of 2 year old Watanabe heritable hyperlipidemic rabbits relative to a population (n = 6) of New Zealand White rabbits. The plasma concentrations were 74 ± 10 nmol/L for the Watanabe group and 47 ± 6 nmol/L for the New Zealand White group. The whole blood concentrations were 364 ± 55 nmol/L for the Watanabe group and 188 ± 64 nmol/L for the New Zealand White group. These results indicate that 4HNE concentrations in blood can be elevated in individuals with atherosclerosis and demonstrate the potential link between the formation of 4HNE and the progression of atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0028222427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028222427&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1994.1280

DO - 10.1006/bbrc.1994.1280

M3 - Article

C2 - 8135808

AN - SCOPUS:0028222427

SN - 0006-291X

VL - 199

SP - 671

EP - 675

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in watanabe heritable hyperlipidemic versus new zealand white rabbits

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this