Whole mouth antimicrobial effects after oral hygiene: Comparison of three dentifrice formulations

Daniel H. Fine, Prem K. Sreenivasan, Marie McKiernan, Debra Tischio-Bereski, David Furgang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Aims This study compared the antimicrobial effects of three commercial dentifrice formulations: sodium fluoride/triclosan/copolymer (TCN/C), stannous fluoride/sodium hexametaphosphate/zinc lactate (SnF2/SHMP) and sodium fluoride (NaF). Materials and Methods Thirty-five adults (15 men and 20 women; average age 33 years and pockets <5 mm) completed this double-blind, triple-crossover study. After washout, baseline samples from four sites, plaque, saliva, tongue and buccal mucosa, were collected and evaluated for six microbial types, anaerobes, Streptococci, Actinomyces, hydrogen-sulphide (H 2S)-producing bacteria, Fusobacteria and Veillonella. A specific dentifrice was randomly assigned for twice-daily use for 13 days. On day 14, 12 h after brushing, samples were collected for microbiological evaluations. Alternate dentifrices followed this identical protocol. Results For all four oral sites and six organisms evaluated in each site, the TCN/C demonstrated significant reductions (49-83%) as compared with the other treatments (p < 0.01). The SnF2/SHMP group showed significant reductions of 14-43% for 14 of 24 outcomes as compared with the NaF group (p < 0.01), with no differences in 10 outcomes. Conclusions The TCN/C dentifrice formulation consistently demonstrated significant reductions for a range of microorganisms in diverse oral sites in comparison with the NaF, or the SnF2/SHMP dentifrice formulations as seen 12 h after brushing.

Original languageEnglish (US)
Pages (from-to)1056-1064
Number of pages9
JournalJournal of Clinical Periodontology
Issue number11
StatePublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Periodontics


  • bacteria
  • brushing
  • buccal mucosa
  • dental plaque
  • dentifrice
  • fluoride
  • saliva
  • stannous fluoride/sodium hexametaphosphate/zinc lactate
  • tongue
  • triclosan/copolymer


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