Worldwide patterns of genomic variation and admixture in gray wolves

Zhenxin Fan, Pedro Silva, Ilan Gronau, Shuoguo Wang, Aitor Serres Armero, Rena M. Schweizer, Oscar Ramirez, John Pollinger, Marco Galaverni, Diego Ortega Del-Vecchyo, Lianming Du, Wenping Zhang, Zhihe Zhang, Jinchuan Xing, Carles Vilà, Tomas Marques-Bonet, Raquel Godinho, Bisong Yue, Robert K. Wayne

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of OldWorld wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalGenome research
Volume26
Issue number2
DOIs
StatePublished - Feb 2016

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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