X chromosomal abnormalities in basal-like human breast cancer

Andrea L. Richardson, Zhigang C. Wang, Arcangela De Nicolo, Xin Lu, Myles Brown, Alexander Miron, Xiaodong Liao, J. Dirk Iglehart, David M. Livingston, Shridar Ganesan

Research output: Contribution to journalArticle

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Abstract

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalCancer Cell
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

Chromosome Aberrations
X Chromosome
Breast Neoplasms
Neoplasms
Aneuploidy
DNA
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Richardson, A. L., Wang, Z. C., De Nicolo, A., Lu, X., Brown, M., Miron, A., ... Ganesan, S. (2006). X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell, 9(2), 121-132. https://doi.org/10.1016/j.ccr.2006.01.013
Richardson, Andrea L. ; Wang, Zhigang C. ; De Nicolo, Arcangela ; Lu, Xin ; Brown, Myles ; Miron, Alexander ; Liao, Xiaodong ; Iglehart, J. Dirk ; Livingston, David M. ; Ganesan, Shridar. / X chromosomal abnormalities in basal-like human breast cancer. In: Cancer Cell. 2006 ; Vol. 9, No. 2. pp. 121-132.
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Richardson, AL, Wang, ZC, De Nicolo, A, Lu, X, Brown, M, Miron, A, Liao, X, Iglehart, JD, Livingston, DM & Ganesan, S 2006, 'X chromosomal abnormalities in basal-like human breast cancer', Cancer Cell, vol. 9, no. 2, pp. 121-132. https://doi.org/10.1016/j.ccr.2006.01.013

X chromosomal abnormalities in basal-like human breast cancer. / Richardson, Andrea L.; Wang, Zhigang C.; De Nicolo, Arcangela; Lu, Xin; Brown, Myles; Miron, Alexander; Liao, Xiaodong; Iglehart, J. Dirk; Livingston, David M.; Ganesan, Shridar.

In: Cancer Cell, Vol. 9, No. 2, 01.02.2006, p. 121-132.

Research output: Contribution to journalArticle

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Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 2006 Feb 1;9(2):121-132. https://doi.org/10.1016/j.ccr.2006.01.013