X chromosomal abnormalities in basal-like human breast cancer

Andrea L. Richardson, Zhigang C. Wang, Arcangela De Nicolo, Xin Lu, Myles Brown, Alexander Miron, Xiaodong Liao, J. Dirk Iglehart, David M. Livingston, Shridar Ganesan

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Abstract

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalCancer Cell
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2006

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Richardson, A. L., Wang, Z. C., De Nicolo, A., Lu, X., Brown, M., Miron, A., Liao, X., Iglehart, J. D., Livingston, D. M., & Ganesan, S. (2006). X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell, 9(2), 121-132. https://doi.org/10.1016/j.ccr.2006.01.013