X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus

Mahendra Madegowda, Subramaniam Eswaramoorthy, Stephen K. Burley, Subramanyam Swaminathan

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Bacillus cereus Hemolysin BL enterotoxin, a ternary complex of three proteins, is the causative agent of food poisoning and requires all three components for virulence. The X-ray structure of the binding domain of HBL suggests that it may form a pore similar to other soluble channel forming proteins. A putative pathway of pore formation is discussed.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalProteins: Structure, Function and Genetics
Volume71
Issue number2
DOIs
StatePublished - May 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology

Keywords

  • HBL-B
  • Hemolysin
  • Pore-formation
  • β-hair-pain

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