Xenobiotic-induced hepatotoxicity: Mechanisms of liver injury and methods of monitoring hepatic function

Marc Sturgill, George H. Lambert

Research output: Contribution to journalArticle

179 Scopus citations

Abstract

Xenobiotic-induced liver injury is a clinically important etiology of hepatic disease that, if not recognized, can lead to hepatic failure. In this article we discuss the mechanisms of xenobiotic-induced liver injury, various factors that can alter the risk and severity of injury, the clinical and laboratory manifestations of injury, and the methods used to detect the presence of injury and (or) functioning liver mass.

Original languageEnglish (US)
Pages (from-to)1512-1526
Number of pages15
JournalClinical Chemistry
Volume43
Issue number8 SUPPL.
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Keywords

  • Ccytochrome P450 enzymes
  • Cytotoxic/cholestatic liver injury
  • Liver function tests
  • Xenobiotic metabolism

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