Xeroderma pigmentosum: Its overlap with trichothiodystrophy, cockayne syndrome and other progeroid syndromes

W. Clark Lambert, Claude E. Gagna, Muriel W. Lambert

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Although this volume is devoted to xeroderma pigmentosum (XP), there are, in fact, at least three disorders, XP, trichothiodystrophy, (TTD) and Cockayne syndrome (CS), the etiopathogeneses of which are involved with the same biochemical pathways and, in a number of cases, with the same gene(s).1-5 In some instances, patients have unequivocal evidence of having more than one of these diseases, which are clinically quite heterogeneous. This chapter will review those unusual cases, known as XP/TTD or XP/CS overlap syndromes or XP/TTD or XP/CS overlap complexes.

Original languageEnglish (US)
Title of host publicationMolecular Mechanisms of Xeroderma Pigmentosum
EditorsShamim Ahmad, Fumio Hanaoka
Pages128-137
Number of pages10
DOIs
StatePublished - 2008

Publication series

NameAdvances in Experimental Medicine and Biology
Volume637
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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