You cannot oxidize what you cannot reach: Oxidative susceptibility of buried methionine residues

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Oxidation of protein methionines to methionine sulfoxides can result in protein structural alterations with a wide variety of biological implications. Factors that determine susceptibility to oxidation are not well understood. The recent JBC Editors Pick by Walker et al. applied proteomic methodologies to show that the oxidative susceptibility of buried methionine residues is strongly correlated with folding stability of the contextual peptide. Proteome-wide analysis of oxidation-susceptible methionines promises to answer open questions about the biological functions of reversible methionine oxidation.

Original languageEnglish (US)
Article number101973
JournalJournal of Biological Chemistry
Volume298
Issue number5
DOIs
StatePublished - May 1 2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'You cannot oxidize what you cannot reach: Oxidative susceptibility of buried methionine residues'. Together they form a unique fingerprint.

Cite this