Zinc as a therapeutic agent in bone regeneration

J. Patrick O'Connor, Deboleena Kanjilal, Marc Teitelbaum, Sheldon S. Lin, Jessica A. Cottrell

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic.

Original languageEnglish (US)
Article number2211
Issue number10
StatePublished - May 1 2020

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics


  • Bone biology
  • Bone healing
  • Bone regeneration
  • Chondrocytes
  • Osteoblasts
  • Osteoclasts
  • Osteogenesis
  • Therapeutics
  • Zinc


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